与乳腺癌患者治疗相关的缺血病的模式,预测因素和预后影响
Bryant Ng1, Armeyra Devani Ferintasari1, Susanna Hilda Hutajulu2
1Medicine Study Program, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
World journal of oncology
|March 31, 2025
概括
在乳腺癌患者中,与治疗相关的缺血病 (TRA) 是常见的. 早期和晚期缺血与改善生存率有关,年龄和激素治疗增加了晚期缺血风险.
科学领域:
- 在瘤学瘤学.
- 生殖内分泌学 生殖内分泌学
背景情况:
- 与治疗相关的缺血症 (TRA) 是绝经前乳腺癌患者经常出现的副作用.
- 了解TRA的发病率,风险因素和预后影响对于患者管理至关重要.
研究的目的:
- 评估TRA在绝经前乳腺癌患者的发病率,风险因素和预后意义.
- 区分早期异常 (EA) 和晚期异常 (LA),以及它们与生存结果的相关性.
主要方法:
- 追溯队列研究涉及81名绝经前乳腺癌患者.
- 在化疗期间和之后通过采访评估月经状况.
- 后勤回归确定了EA和LA的风险因素;卡普兰-梅尔和考克斯分析评估了对3年总生存期 (OS) 的影响.
主要成果:
- TRA发生在82.7% (EA) 和55.6% (LA) 的患者中.
- 对LA的独立风险因素包括年龄超过45岁和荷尔蒙治疗;转移性疾病降低了LA风险.
- EA和LA都与改善的3年OS有显著的关联 (HR<1对两者来说).
结论:
- 年龄超过45岁和荷尔蒙治疗增加LA风险;转移性疾病具有保护作用.
- 在乳腺癌患者中,EA和LA都预测了有利的3年生存期.
- 标准化TRA评估对于未来的研究和临床指导至关重要.
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