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适应性临床试验文章的索引问题
Neil R Smalheiser1, Andrew Shahidehpour1, Ang Michael Troy1
1Department of Psychiatry, University Of Illinois College of Medicine, Chicago, IL 60612 USA.
在PubMed中对适应性临床试验的索引显示了重大错误. 超过24%的文章被错误分配,影响了证据检索和临床决策.
科学领域:
- 生物医学信息学 生物医学信息学
- 临床试验方法论 临床试验方法论
背景情况:
- 准确的生物医学文献索引对于基于证据的实践和研究至关重要.
- 适应性临床试验,其中干预措施根据参与者数据而有所不同,是复杂的研究设计.
研究的目的:
- 评估PubMed中归类为"适应性临床试验"的文章索引的准确性.
- 为了确定本类出版物索引错误的程度和性质.
主要方法:
- 在"适应性临床试验"的出版物类型下分类的PubMed文章的手动审查.
- 根据文章的具体研究设计与更大的试验背景对索引准确性的评估.
主要成果:
- 发现很大一部分文章有错误或可疑的索引决定.
- 46.7%的文章被错误分配,如果严格按照自己的设计进行索引.
- 即使在考虑部分结果时,调整后的错误率仍然为24.2%.
结论:
- 目前在PubMed中适应性临床试验的索引实践包含重大错误.
- 这些索引不准确可能会阻碍有效的文献检索,并可能影响临床决策和研究综合.
- 为提高索引一致性和准确性提出建议是有必要的.
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