放射性治疗对甲状腺癌患者的血液学参数的影响:系统性审查和元分析
Dereje Mengesha Berta1, Bisrat Birke Teketelew1, Negesse Cherie2
1Department of Hematology and Immunohematology, School of Biomedical and Laboratory Science, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.
Frontiers in endocrinology
|March 31, 2025
概括
甲状腺癌的放射性治疗显著影响血液细胞计数,包括白细胞,中性粒细胞,淋巴细胞和血小板. 早期监测和管理这些血液学变化对于患者的健康至关重要.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 核医学是一种核医学.
背景情况:
- 甲状腺癌 (TC) 治疗通常涉及放射性治疗 (RIA).
- RIA可能会对血液细胞 (血液学参数) 产生显著的副作用.
- 报告的血液学参数变化在不同研究中存在差异,需要进行全面的评估.
研究的目的:
- 在甲状腺癌患者接受放射性治疗后,系统地审查和评估血液学参数的平均差异.
- 量化RIA对白细胞总数,绝对中性粒细胞数,绝对淋巴细胞数,血小板数,红细胞和血红蛋白的影响.
主要方法:
- 通过数据库和谷歌进行了系统的文献搜索.
- 用资格标准来选择相关的文章.
- 使用随机效应模型计算血液学参数的聚合标准化平均差异 (SMD).
- 使用I2统计数据评估异质性,使用漏斗图表和埃格尔测试评估出版偏差.
主要成果:
- 包括17项涉及4,112名 (RIA前) 和3,766名 (RIA后) 参与者的研究.
- 在多个时间点观察到全白细胞计数 (TLC) 的统计学显著变化.
- 在最后一次随访时,观察到绝对中性粒细胞计数 (ANC),绝对淋巴细胞计数 (ALC) 和血小板计数 (PLT) 的显著变化.
- 红细胞 (RBC) 和血红蛋白 (Hgb) 水平也在治疗后的特定间隔显示出统计学上显著的变化.
结论:
- 放射性治疗对甲状腺癌患者的各种血液学参数产生重大影响.
- 建议早期查和管理RIA诱导的血液毒性.
- 解决这些副作用可能会改善接受RIA治疗的患者的生活质量.
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