饮食引起的MASLD的性别差异 - 雌性小鼠是否受到自然保护?
Jana Meyer1, Ana Mendes Teixeira1, Sandy Richter1
1Center for Pediatric Research, University Hospital for Children and Adolescents, Leipzig University, Leipzig, Germany.
Frontiers in endocrinology
|March 31, 2025
概括
雄性小鼠从高脂肪饮食中发展出肝纤维化,与雌性不同,由于子宫外脂质的积累. 雌激素受体可能为代谢功能障碍相关的脂肪性肝病 (MASLD) 治疗提供治疗点.
科学领域:
- 肝病学和代谢研究.
- 疾病发病的性别差异 疾病发病的性别差异
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 在男性中表现出更高的患病率和严重程度.
- 导致MASLD发育和进展的性别差异的确切机制仍然不完全理解.
研究的目的:
- 在小鼠模型中调查饮食诱导的MASLD和相关的肝纤维化发展的性别特异性.
- 探索雌激素受体在调解这些性别特异性反应中的作用.
主要方法:
- 雄性和雌性小鼠被食"快餐"饮食 (FFD) 或控制饮食 (CD) 一段时间.
- 评估了代谢参数,肝脏组织学和纤维化标记物 (Tgfb1,Col1a1) 和雌激素受体 (Esr1,Esr2) 的基因表达.
主要成果:
- 由FFD诱导的MASLD导致两性之间有明显的表型:女性在脂肪组织中积累了脂质,而男性表现出异胎性肝脂沉积,肝膨胀和显著纤维化.
- 男人表现出转化生长因子β 1 (Tgfb1) 和原I (Col1a1) 表达的增加,表明纤维化,而女性则没有.
- 雌激素受体β (Esr2) 在男性肝脏上调,而雌激素受体α (Esr1) 表达在女性肝脏中更高.
结论:
- 性对MASLD的发展和肝纤维化产生深刻影响,这是对西方风格饮食的反应.
- 雌激素受体,特别是Esr1和Esr2,在饮食引起的肝病的性别特异性病原发生中发挥作用.
- 向雌激素受体是一种潜在的治疗策略,可以减轻MASLD中饮食诱导的肝纤维化.
更多相关视频
06:18An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
12.1K
05:44Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
Published on: October 13, 2023
1.2K
相关概念视频
02:45The Ratio of X Chromosome to Autosomes
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
02:50Dosage Compensation
In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will have...
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will have...