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兹维特里奥尼克分子印制的毛纤维素纳米晶体使选择性万科米辛去除成为可能

Roya Koshani¹, Shang-Lin Yeh¹, Sina Kheirabadi¹

¹Department of Chemical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.

Langmuir : the ACS journal of surfaces and colloids

|March 31, 2025

概括

研究人员开发了新型纳米纤维素材料,可以选择性地从肠道中去除万科米辛 (VAN),通过捕获非目标抗生素剂量,潜在地减少抗菌素耐药性 (AMR).

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
抗微生物耐药性研究研究

背景情况:

抗菌素耐药性 (AMR) 是一个日益增长的全球健康威胁.
在胃肠道中的非向抗生素剂量,如万科米辛 (VAN),有助于AMR.
选择性地从肠液中去除VAN是具有挑战性的,因为有竞争分子.

研究的目的:

设计一种用于选择性从胃肠道中去除万科米辛的新材料.
为了应对选择性抗生素捕获中的竞争性吸附的挑战.
开发一种生物基解决方案,以缓解AMR演变.

主要方法:

制造VAN打印的聚合的zwitterionic毛纤维素纳米晶体 (ViPZ-HCNC).
评估VAN捕获能力和选择性与其他生物分子 (lysine,lyszyme,albumin) 相比.
在模拟的肠液中测试ViPZ-HCNC,并评估细胞毒性.

主要成果:

ViPZ-HCNC表现出高的VAN去除能力 (∼235毫克-1),其印记因子为∼7.5.
在素,酶和牛血清白蛋白上对VAN取得了很好的选择性.
从含离子的溶液和模拟的肠液中有效地去除VAN,没有毒性.

结论:

ViPZ-HCNC代表了第一个以纳米纤维素为基础的材料,具有对VAN捕获的高选择性.
这种材料有效地将VAN从复杂的生物介质中去除,提供了对抗AMR的潜在策略.
ViPZ-HCNC提供了一个有前途的基于生物的平台,用于开发软材料,以对抗AMR演变.

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