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Updated: May 16, 2025

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
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通过C-H激活对异环的机械化学功能化:最新情况

Mainak Banerjee1, Abboy Chatterjee1, Shaurya Aneja1

  • 1Department of Chemistry, Birla Institute of Technology and Science Pilani, KK Birla Goa Campus, NH 17B Bypass Road, Zuarinagar, Goa, 403726, India.

The Journal of organic chemistry
|March 31, 2025
PubMed
概括

机械化学提供了一种可持续的,无溶剂的方法来激活异环中C-H键,这对于药物发现至关重要. 本综述涵盖了绿色,机械化学方法的最新进展,以使这些重要的分子支架发挥作用.

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Cycloaddition Reactions: MO Requirements for Photochemical Activation

Some cycloaddition reactions are activated by heat, while others are initiated by light. For example, a [2 + 2] cycloaddition between two ethylene molecules occurs only in the presence of light. It is photochemically allowed but thermally forbidden.
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All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the...
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