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发现一种基于花粉提取物和tipolioside的新型营养药:一项前性单心研究,评估其在减轻良性前列腺增生患者下尿路症状中的作用
Mattia Lo Re1, Marta Pezzoli2, Anna Cadenar3
1Unit of Oncologic Minimally Invasive Urology and Andrology, University of Florence, Careggi Hospital, Florence; Department of Experimental and Clinical Medicine, University of Florence. mattialore1994@gmail.com.
概括
花粉提取物和tapolioside的组合有效地治疗患有良性前列腺增生症 (BPH) 的男性下泌尿道症状 (LUTS). 这项研究显示了显著的症状改善和良好的安全性,避免性功能障碍.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
- 营养保健品 营养保健品
背景情况:
- 良性前列腺增生 (BPH) 是一种普遍影响50岁以上男性的疾病,引起下泌尿道症状 (LUTS).
- 一种结合花粉提取物 (Graminex® G96®) 和tépolioside的营养药正在研究其通过调节炎症和二二 (DHT) 生产来降低LUTS的潜力.
- 这项研究侧重于患有轻度至中度LUTS的患者,归因于BPH.
研究的目的:
- 评估一种特定的营养药物配方在管理与BPH相关的LUTS的疗效和安全性.
- 评估治疗对尿道症状得分,生活质量和尿动力学参数的影响.
- 为了确定对性功能和前列腺特异性抗原 (PSA) 水平的影响.
主要方法:
- 一项前性,单心研究,涉及60名男性参与者,患有轻度至中度BPH相关的LUTS.
- 参与者每天服用1片营养药,持续3个月.
- 关键评估包括国际前列腺症状评分 (IPSS),生活质量 (QoL) 问卷,尿液流量计,空白后残留量 (PVR) 和验证的性功能指数 (IIEF-5,MSHQ EjD).
主要成果:
- 在治疗三个月后,IPSS和QoL得分 (p<0.001) 显著改善.
- 尿液流量计显示最大流量 (Qmax) 的改善趋势和PVR的降低,尽管在统计上不显著 (p>0.05).
- 性功能参数和PSA水平保持稳定,在研究期间没有报告任何重大不良事件.
结论:
- 结合的花粉提取物和tapolioside配方在缓解BPH患者的LUTS方面表现出有效性.
- 这种治疗表现出良好的安全性,特别是保持性功能.
- 这种营养药物代表了一种可行的选择,用于管理BPH症状,并具有最小的副作用.
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