补充Pycnogenol®可以缓解具有显著血管炎成分的慢性炎症疾病的症状:一个试点注册研究
Gianni Belcaro1, Shu Hu2, Maria R Cesarone2
1Irvine3 Labs, PAP/PEA Screening Project, Pescara, Italy - gianni@belcarocardres.it.
补充Pycnogenol (法国海上松树皮提取物) 在患有血管炎疾病的患者中安全地减少了残留症状和炎症标志物. 这可能提供一种替代的管理策略,可能防止疾病复发.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 自然产品化学 自然产品化学
背景情况:
- 研究Pycnogenol (法国海上松树皮提取物) 用于血管炎缓解的抗炎治疗.
- 专注于系统性红斑狼,贝赫特病,斯乔格伦综合征和多关节性关节炎.
- 包括那些症状很小,持续性很小,不接受慢性药物治疗的患者.
研究的目的:
- 评估口服Pycnogenol对残留炎症症状的安全性和预防性影响.
- 评估血管炎患者症状复发的潜在影响.
- 进行为期4周的开放标签补充注册研究.
主要方法:
- 124名患有血管炎的患者参与了这项研究.
- 63人接受了Pycnogenol (150毫克/天),61人作为对照.
- 监测症状得分,炎症标志物 (ESR,IL-6),NSAID/皮质类固醇使用和氧化应激.
主要成果:
- 补充Pycnogenol是安全的,没有观察到副作用.
- 在Pycnogenol组中,症状得分,ESR和高IL-6水平显著降低.
- 在补充剂的患者中,对NSAID/皮质类固醇的需求降低,并减少了血氧化应激.
结论:
- 补充Pycnogenol显示了管理血管炎疾病的潜力,可能避免更严厉的药物治疗.
- 慢性使用Pycnogenol可以预防血管炎相关疾病的临床显著复发.
- 进一步研究长期影响和预防是有必要的.
更多相关视频
06:43Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses
Published on: March 29, 2017
06:35An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
相关概念视频
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Inflammation
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
