用免疫检查点抑制剂治疗转移性黑色素瘤患者的手术
Joséphine C Janssen1,2, Anne E Huibers3,4, Dirk J Grünhagen1
1Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
概括
手术在治疗转移性黑色素瘤方面正在重新获得重要性,特别是当与免疫检查点抑制剂相结合时. 在这些疗法后进行完整的外科切除可能会改善转移性黑色素瘤患者的生存率.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 免疫治疗是一种免疫疗法.
背景情况:
- 转移性黑色素瘤的治疗与全身疗法一起演变.
- 免疫检查点抑制剂 (ICI) 最初减少了手术的作用.
- 最近的证据表明,在ICI时代,外科手术起到了新的作用.
研究的目的:
- 审查手术在转移性黑色素瘤中不断变化的作用.
- 探索ICI的外科指示和结果.
- 检查手术和全身疗法的整合.
主要方法:
- 现有文献的叙述性审查.
- 对转移性黑色素瘤手术研究的分析.
- 在免疫检查点抑制剂的背景下对结果的评估.
主要成果:
- 回顾性研究表明,切除患者的生存益处.
- 完全切除 (没有疾病的证据) 与更好的结果有关.
- 当与现代疗法的客观反应相结合时,外科手术的作用会得到增强.
结论:
- 在精选的转移性黑色素瘤病例中,手术仍然是关键组成部分.
- 与免疫检查点抑制剂的整合显示出有希望的生存益处.
- 进一步的研究应该专注于优化手术时间和患者选择.
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