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Updated: May 16, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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延长p53误解变异R248Q的半衰期促进与野生类型p53的积累和异质四聚体形成,以产生主导负效应

Nancy Klemm1, Roman R Schimmer1, Nils K Konrad1

  • 1University Hospital Zurich and University of Zurich, Zurich, Switzerland.

Cancer research
|March 31, 2025
PubMed
概括

像R248Q这样的Missense p53突变因形成与野生类型 (WT) p53.3的异构基因而引起主导负效应 (DNE). 降低R248Q水平恢复了WT p53功能,并显示了癌症的治疗潜力.

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