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一个基于网络的定制干预的随机对照试验,以增加艾滋病毒/艾滋病感染者的人类乳头瘤病毒疫苗接种率
Kaliane Caldas de Brito1, Miralba Freire de Carvalho Ribeiro da Silva2, Cristiane Wanderley Cardoso3
1Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Bahia, Brazil.
PloS one
|March 31, 2025
概括
一个基于网络的干预措施显著增加了艾滋病毒/艾滋病患者的HPV疫苗接种率. 针对这一群体量身定制的e-HPV工具显示,与标准信息相比,接种疫苗的意图和启动率更高.
科学领域:
- 公共卫生 公共卫生
- 疫苗学 疫苗学 疫苗学
- 医疗信息学 医疗信息学
背景情况:
- 人类乳头瘤病毒 (HPV) 引起癌症,不成比例地影响着艾滋病毒/艾滋病感染者 (PLWH).
- 关于在PLWH中增加HPV疫苗使用的干预措施的研究有限.
- 需要有效的策略来促进HPV疫苗接种在这个脆弱的人群中.
研究的目的:
- 评估基于网络的定制干预措施 (e-HPV) 的有效性,以促进PLWH中的HPV疫苗接种.
- 评估e-HPV干预对HPV疫苗的意图和启动的影响.
主要方法:
- 一项随机对照试验对654名18-45岁的PLWH进行了随机对照试验.
- 参与者被随机分配,接受电子HPV干预或标准健康信息.
- 测量结果包括接种疫苗的意愿和疫苗启动.
主要成果:
- 与对照组相比,e-HPV组的打算接种疫苗的意向大约是两倍 (OR=2.0) 和显著更高的疫苗启动率 (OR=2.1).
- 相信疫苗的有效性,风险感知和感知到HPV感染的严重程度是关键的动机.
- 这种干预被认为是可以接受和有效的.
结论:
- 电子HPV干预是增加PLWH中HPV疫苗接种的有效策略.
- 需要进一步的研究来优化和实施e-HPV干预在为PLWH服务的临床环境中.
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