在子中由Folium sennae诱导的微生物组和代谢变化
Houkang Ding1, Ming Li2, Ning Ma1
1Department of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Hebei Agricultural University, Baoding, Hebei, China.
PloS one
|March 31, 2025
概括
叶 (Folium Sennae) 提取物 (FSAE) 在子中诱导腹,改变肠道微生物群和代谢. 这项研究揭示了神经递质和微生物群体的变化,为胃肠道功能障碍机制提供了洞察力.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 腹显著影响牲畜的生产力和福利.
- 现有的牲畜腹治疗方法包括益生菌,益生菌,有机酸和抗生素.
- 了解腹的潜在机制对于开发有效疗法至关重要.
研究的目的:
- 为了研究子诱导腹的微生物组和代谢变化,使用树叶提取物 (Folium Sennae提取物 (FSAE)).
- 阐明肠道微生物群,代谢学和胃肠道功能障碍之间的相互作用.
- 为研究胃肠道 (GIT) 功能障碍和潜在治疗方法建立一种新型模型.
主要方法:
- 在子中,通过FSAE的口服测量诱导了腹.
- 评估的体重,腹指数,血清生物化学指标,以及他的病理学.
- 分析了肠道微生物组成和结肠组织代谢学.
主要成果:
- 在子中,FSAE的使用导致了更高的腹指数和体重减轻.
- 观察到神经递质和激素的血清水平发生了显著的变化 (例如,增加了体静止素,物质P;减少了胃素,素).
- 减少了微生物多样性和变化的种群 (减少了Firmicutes,Campilobacterota,Proteobacteria),以及结肠组织中失调的关键代谢物.
结论:
- 在子中,FSAE诱导的腹的特征是体系病理学变化,改变的血清标记物和肠道失调 (微生物群和代谢学).
- 这项研究为FSAE诱导的腹和GIT功能障碍的机制提供了新的见解.
- 这些发现为研究胃肠道疾病和治疗策略建立了有价值的模型.
更多相关视频
08:14A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
Published on: February 28, 2018
8.7K
05:28Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method
Published on: May 2, 2022
2.0K
相关概念视频
01:30Development of Human Microbiota
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
01:27Microbiota of the Large Intestine
The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...