高血压,血脑屏障的破坏和内压力的变化
Eduardo Colombari1, Vinícia Campana Biancardi2, Débora Simões Almeida Colombari1
1Department of Physiology and Pathology, School of Dentistry of Araraquara, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil.
高血压通过破坏血脑屏障并损害大脑的服从,危险地提高了内压力 (ICP). 了解这些影响是预防高血压患者神经功能障碍和中风的关键.
科学领域:
- 神经学 神经学
- 心血管科学 心血管科学
- 神经科学是一个神经科学.
背景情况:
- 内压力 (ICP) 对大脑健康至关重要,由大脑组织,脑脊液 (CSF) 和大脑血液体积的平衡维持.
- 升高的ICP,或内高血压 (IH),是由于诸如出血或水脑等障碍造成的.
- 系统性高血压严重影响大脑健康,导致微血管损伤,血脑屏障 (BBB) 功能障碍,以及减少内合规 (ICC).
研究的目的:
- 审查高血压和ICP调节之间的复杂关系.
- 阐明高血压状态下ICP和ICC调整的机制.
- 强调BBB完整性和脑血流动力学 (CBF) 的作用.
主要方法:
- 文献综述侧重于系统性高血压和内压力动态之间的相互作用.
- 在高血压条件下影响ICP和ICC的机制的分析.
- 检查神经血管单元在高血压引起的内高血压中的作用.
主要成果:
- 高血压会损害BBB的完整性,减少内服从,改变大脑血流调节,增加IH的风险.
- 在高血压中,交感神经系统功能障碍加剧了受损的CBF调节和ICP维护.
- 神经血管单元对高血压患者的IH有贡献,影响神经功能.
结论:
- 高血压对大脑健康构成重大风险,包括IH,缺血和中风.
- 需要针对BBB完整性,炎症和大脑遵守的治疗策略.
- 对高血压的早期检测和干预对于预防严重的神经后果至关重要.
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