背上条纹体的光遗传刺激双向控制了发作
Safwan K Hyder1, Willian Lazarini-Lopes1, Jonathan Toib1
1Department of Pharmacology and Physiology, Georgetown University, Washington, DC 20007.
概括
研究人员探索了背上条纹体.
科学领域:
- 神经科学是一个神经科学.
- 的研究研究.
- 神经调节是一种神经调节.
背景情况:
- 抗发作药物和深度大脑刺激对不是普遍有效的.
- 背上条纹体在控制中的作用仍未得到充分研究.
- 对不同类型的发作需要新的治疗点.
研究的目的:
- 为了研究背上条纹体在控制各种发作类型中的作用.
- 评估光遗传学激活和非激活背带状神经元对发作的影响.
主要方法:
- 在老鼠中,背部条状神经元的光遗传激活和非激活.
- 使用了三种模型:由-丁 (GBL) 诱导的缺席,杏仁核燃烧和皮洛卡尔诱导的状态 (SE).
- 采用了开环和闭环光遗传刺激.
主要成果:
- 背部条状神经元的光遗传激活在所有测试模型中抑制了发作.
- 沉默背部条状神经元加剧了缺席,并促进了SE发作,但没有影响着发作.
- 闭环激活在GBL模型中减少了尖峰波放电持续时间,而抑制则增加了它.
结论:
- 背上条纹体在控制多种发作类型方面发挥着重要的双向作用.
- 状神经调节显示了以前未知的抗缺席效应.
- 背上条纹体是广泛的控制疗法的潜在目标.
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