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Updated: May 17, 2025

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
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Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

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在T细胞急性淋巴细胞白血病中针对NOTCH1和内滴化通路的治疗向

Kalay Bertulfo1,2, Pablo Perez-Duran1, Hannah Miller1

  • 1Institute for Cancer Genetics, Columbia University, New York, NY 10032.

Proceedings of the National Academy of Sciences of the United States of America
|March 31, 2025
PubMed
概括

玛分泌酶抑制剂 (Gamma Secretase Inhibitors,GSI) 通过阻断NOTCH1.1,治疗T细胞急性淋巴细胞白血病 (T-ALL). 将GSI与MLN4924结合起来可以预防肠道毒性,并改善T-ALL模型中的存活率.

关键词:
HES1 HES1 的时间在NOTCH1中,在T细胞淋巴细胞白血病 (T-ALL) 中.实验性治疗学实验性治疗学没有脱,没有脱.

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