活性药物成分组合的兼容性 结合在CleodermTM中,这是个性化皮肤治疗的奶油基础
Bruna Marianni1, Carolina Costa Vicente Silva1, Hudson Polonini1
1Fagron BV, Rotterdam, The Netherlands.
International journal of pharmaceutical compounding
|March 31, 2025
概括
在CleodermTM奶油基中的复合皮肤学配方表现出不同的稳定性. 阿达巴林/过氧化物,阿泽拉酸/尼亚胺和尼亚胺/丁胺配方稳定180天,而其他配方的使用过期日期 (BUD) 较短.
科学领域:
- 皮肤病学 皮肤病学
- 制药科学 制药科学
- 化品科学 化品科学
背景情况:
- 越来越多的皮肤疾病,如,粉红和色素过高,需要个性化治疗.
- 结合多种活性药物成分 (API) 的复合配方提供了量身定制的皮肤病解决方案.
- 克利奥德尔姆TM是一款针对容易,受影响或敏感的皮肤而开发的奶油基.
研究的目的:
- 评估CleodermTM中各种复合性皮肤学配方的兼容性和稳定性.
- 为这些配方确定基于证据的过期使用日期 (BUDs).
- 为了确认测试配方的抗微生物疗效.
主要方法:
- 在CleodermTM中制备了含有阿达巴林,甲氧化物,化,皮,化,化,阿泽莱克酸,氨酸和克林达米辛化的配方.
- 使用高性能液态染色学 (HPLC) 在180天内评估稳定性.
- 进行了微生物学评估,以根据美国药典 (USP) 标准评估抗微生物药物的有效性.
主要成果:
- 配合阿达巴烯和甲氧化物,阿泽拉酸和氨酸,氨酸和氨酸的配方表现出稳定性,BUD为180天.
- 含有化,皮和特里诺因以及克林达米辛化的配方的BUD为14天.
- 所有配方在各自的BUD中都符合USP对抗微生物有效性的要求.
结论:
- 克利奥德尔姆TM是一种多功能基础,用于复合皮肤学配方,支持个性化治疗.
- 特定配方已经证明了长期稳定性 (180天),而其他配方则需要更短的BUD (14天).
- 该研究提供了关于稳定性和BUDs的关键数据,以确保复合性皮肤治疗的安全性和有效性.
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