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喉 dystonia 的神经调节: 一个系统的审查
Chang Woo Lee1, Marie T Krüger2, Harith Akram2
1Department of Laryngology, National Voice Centre, Royal National ENT Hospital, University College London Hospitals NHS Foundation Trust, London, United Kingdom; UCL Division of Surgery and Interventional Science, London, United Kingdom.
本综述探讨了用于喉 dystonia (LD) 的神经调节疗法. 在早期阶段,氧酸盐和深度大脑刺激 (DBS) 显示出治疗LD症状的前景.
科学领域:
- 神经学 神经学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 生物医学工程 生物医学工程
背景情况:
- 喉 dystonia (LD),也被称为性语音障碍,是一个使人虚弱的神经语音障碍.
- 目前对LD的治疗选择有局限性,需要探索新的治疗方法.
研究的目的:
- 系统地审查和评估神经调节疗法用于喉 dystonia.
- 评估这些疗法在临床实践中的现有证据和潜力.
主要方法:
- 根据PRISMA指南进行了系统的文献审查.
- 在Embase,Medline和Cochrane数据库 (1960-2024) 上进行了搜索.
- 包括的研究使用Joanna Briggs研究所的检查清单进行了偏差评估,并提取了患者人口统计学,治疗方法,结果和并发症的数据.
主要成果:
- 涉及130名患者的12项研究评估了包括振动触觉刺激,喉电刺激,氧酸,重复性跨磁刺激和深度大脑刺激 (DBS) 在内的疗法.
- 所有研究都报告了语音症状的改善,但关于疗效的最终结论受到研究设计 (病例报告,试点研究,I期试验) 和缺乏长期随访的限制.
- 在任何研究的神经调节疗法中都没有报告任何重大并发症.
结论:
- 对于LD的神经调节疗法主要处于早期探索阶段.
- 需要进一步的临床试验来确定疗效和安全性.
- 氧酸盐和DBS在治疗喉 dystonia. 在未来的临床应用中显示出最大的潜力.
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