Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Combinatorial Gene Control02:33

Combinatorial Gene Control

8.2K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
8.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Blood-Based Epigenetic Aging Signatures in D3GHR Carriers: An Exploratory Pilot Study of Metabolic Adaptation and Aging-Related Pathways.

International journal of molecular sciences·2026
Same author

Genome integrity, somatic mutation, and the N-of-1 imperative in aging research.

Biogerontology·2026
Same author

Epigenetics as Biomarkers of Cumulative Physical Performance in Community-Dwelling Adults: A Cross-Sectional Feasibility Study.

Cells·2026
Same author

Licking microstructure behavior classifies a spectrum of emotional states in mice.

Frontiers in systems neuroscience·2025
Same author

Microgravity Therapy as Treatment for Decelerated Aging and Successful Longevity.

International journal of molecular sciences·2025
Same author

High Genetic Diagnostic Yield for Patients with Rare Movement Disorders at a Single-Center Neurogenetics Clinic.

Movement disorders clinical practice·2025
Same journal

Poly(bromophenol blue)/CoSn(OH)<sub>6</sub> cubic particles modified pencil graphite electrode for electrochemical determination of diphenhydramine.

Scientific reports·2026
Same journal

Dietary Chlorella, Spirulina, and acidifier modulate jejunal cytokine-related gene expression in broiler chickens.

Scientific reports·2026
Same journal

Perceived physical activity barriers in university students: associations with fatigue and eating behaviours.

Scientific reports·2026
Same journal

Refuge limitation structures habitat use in agricultural landscapes: evidence from Sunda pangolins.

Scientific reports·2026
Same journal

Lightweight stateless transaction verification with outsourced witness updates for UTXO blockchains.

Scientific reports·2026
Same journal

Efficacy of historical context and exogenous features on deep learning for cooling load forecasting in chilled water plants.

Scientific reports·2026
查看所有相关文章

相关实验视频

Updated: May 16, 2025

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
12:25

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

Published on: February 24, 2023

767

一个用于检测随着衰老而发生的组织间基因表达协调变化的计算框架.

Shaked Briller1, Gil Ben David2, Yam Amir2,3

  • 1Department of Information Systems, University of Haifa, Haifa, Israel.

Scientific reports
|March 31, 2025
PubMed
概括
此摘要是机器生成的。

这项研究引入了一种新的计算方法来分析多种组织中的基因表达协调如何随着年龄的增长而变化. 该方法确定了参与衰老的关键基因和途径,有助于制定健康衰老策略.

更多相关视频

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

35.0K
SA-&#946;-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

23.7K

相关实验视频

Last Updated: May 16, 2025

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome
12:25

Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

Published on: February 24, 2023

767
Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

35.0K
SA-&#946;-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

23.7K

科学领域:

  • 基因组学就是基因组学.
  • 计算生物学 计算生物学
  • 衰老研究研究 衰老研究

背景情况:

  • 衰老是一个复杂的生物过程,受到许多基因和途径的影响.
  • 现有的研究往往侧重于组织特异性衰老,忽视组织间分子通路相互作用.
  • 了解跨组织衰老机制对于开发有效干预措施至关重要.

研究的目的:

  • 开发和验证一种新的计算框架,用于在多种组织中分析与年龄相关的基因表达模式.
  • 识别关键的组织间基因和生物通路,这些基因和生物通路是衰老的特征.
  • 探索不同组织类型的衰老背后的协调分子变化.

主要方法:

  • 使用了调整后的多组织权重基因共同表达网络分析.
  • 在不同年龄组之间进行了差异网络连接分析.
  • 机器学习模型 (XGBoost和随机森林) 用基因表达和通路得分进行分类.

主要成果:

  • 随机森林模型在预测年龄组方面取得了很高的准确性 (AUC < 88%),突出了关键的组织间基因.
  • 关键的与衰老相关的途径涉及脂质代谢,免疫系统功能和细胞通信,在整个组织中被确定.
  • 还检测到了不同的组织特异性衰老途径,强调了组织异质性.

结论:

  • 开发的框架有效地揭示了组织间协调在衰老过程中的重要性.
  • 这些发现提供了关于衰老机制和促进健康衰老的潜在治疗点的宝贵见解.
  • 这种方法可以指导未来对衰老系统性质的研究以及针对性干预措施的开发.