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Updated: May 5, 2026

Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques
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Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques

Published on: June 1, 2016

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人类大脑和其他生物模型的相对光和电子显微镜

Notash Shafiei1,2, Daniel Stӓhli1,2, Domenic Burger1,2

  • 1Laboratory of Biological Electron Microscopy, Institute of Physics, School of Basic Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

Nature protocols
|March 31, 2025
PubMed
概括

我们在人脑组织中介绍了室温相关光和电子显微镜 (CLEM) 的详细方案. 这种为期8天的方法使得用于疾病研究的高分辨率超结构分析成为可能.

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Correlative Light- and Electron Microscopy Using Quantum Dot Nanoparticles11:16

Correlative Light- and Electron Microscopy Using Quantum Dot Nanoparticles

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Author Spotlight: Advancing 3D Cytoarchitecture Analysis - Rapid Volumetric Reconstruction of the Human Brain

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相关概念视频

Overview of Electron Microscopy01:25

Overview of Electron Microscopy

The wavelengths of visible light ultimately limit the maximum theoretical resolution of images created by light microscopes. Most light microscopes can only magnify 1000X, and a few can magnify up to 1500X. Electrons, like electromagnetic radiation, can behave like waves, but with wavelengths of 0.005 nm, they produce significantly greater resolution up to 0.05 nm as compared to 500 nm for visible light. An electron microscope (EM) can create a sharp image that is magnified up to 2,000,000X.
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