来自407名健康受试者的ISCEV标准全场ERG参考值,来自电极类型和中心之间的参考数据的转移和验证
Rebecca A Baker1, Shaun M Leo1,2, William I N Clowes1
1Moorfields Eye Hospital NHS Foundation Trust, 162 City Road, London, EC1V 2PD, UK.
Documenta ophthalmologica. Advances in ophthalmology
|March 31, 2025
概括
这项研究确定了使用银线电极进行电网光学 (ERG) 的年龄调整的参考间隔. 来自金电极的数据已成功转换,为标准化和临床使用创建了一个强大的参考样本.
科学领域:
- 眼科医生 眼科 眼科
- 神经生理学 神经生理学
- 医疗成像医学成像
背景情况:
- 国际临床视觉电生理学学会 (ISCEV) 提供了全场电网红图 (ERG) 测试的标准.
- 建立可靠的,年龄调整的参考间隔对于准确的ERG数据临床解释至关重要.
- 之前的研究使用了各种类型的电极,需要数据协调.
研究的目的:
- 通过使用银线电极,为ISCEV标准的全场电网红图 (ERG) 建立年龄调整的参考间隔.
- 为了确定用银线和金电极记录的ERG数据的可比性.
- 开发用于汇集来自多个中心和电极类型的参考数据的方法.
主要方法:
- 从两个中心 (n=251) 收集并验证了银线下方方的ERG参考数据.
- 使用银线,金和皮肤电极 (分别n=53和n=41) 进行ERG记录的比较.
- 利用线性模型转换金ERG数据,将其纳入银线参考范围,创建一个组合样本 (n=407).
主要成果:
- 银丝线ERG数据在两个中心一致,支持数据聚合.
- 黄金和银线ERG的高峰时间显示高可比性 (r2=0.75-0.98).
- 银线ERG的振幅为金ERG的55-65%,皮肤ERG为银线ERG的35-38%.
结论:
- 通过ISCEV标准的银线ERG数据在各个中心保持一致,从而实现数据传输.
- 金ERG数据可以调整为包含在银线参考范围.
- 该研究提供了一个强大的方法来汇集参考数据,有利于标准化和多中心研究.
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