改变精子捐赠者是怀孕的捷径还是神话?
Shimi Barda1,2, Yael Eliner3,4, Noga Fuchs Weizman3,5
1The Institute for the Study of Fertility and Racine IVF Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, 6 Weizman Street, 6423906, Tel Aviv, Israel. shimib@tlvmc.gov.il.
Journal of assisted reproduction and genetics
|March 31, 2025
概括
在子宫内授精 (IUI) 周期失败后切换精子捐赠者可以减少怀孕所需的额外周期的数量. 这表明精子-卵细胞的兼容性可能会影响IUI的成功率.
科学领域:
- 生殖医学 生殖医学
- 不孕症治疗 不孕症治疗
- 精子捐献 精子捐献
背景情况:
- 捐赠精子子子宫内授精 (IUI) 是一种常见的生育治疗方法.
- 在IUI周期失败后切换精子捐赠者的做法很普遍,但没有得到充分的研究.
- 了解影响IUI成功的因素对于优化患者治疗结果至关重要.
研究的目的:
- 评估转换精子捐赠者对实现怀孕所需的IUI周期数量的影响.
- 调查精子捐赠者兼容性是否在IUI成功中起作用.
主要方法:
- 对312名接受捐赠精子IUI (1992-2020) 的女性进行了回顾性队列研究.
- 使用一位捐赠者 (A组) 和转换捐赠者 (B组) 的妇女之间的受孕率的比较.
- 统计分析包括t测试,ANOVA和MANCOVA来确定周期计数和活产率.
主要成果:
- 使用单一供体的女性比使用单一供体的女性需要更少的循环 (3.78),相比于使用单一供体的妇女需要更少的循环 (6.07).
- 然而,在转换后,B组需要的额外循环 (2.23) 比A组的总循环要少得多.
- 累积活产率在A组 (6周期为81.5%) 与B组 (6周期为61.9%) 相比较高.
结论:
- 在多次不成功的IUI周期后切换精子捐赠者显著减少了怀孕所需的后续周期的数量.
- 研究结果表明,潜在的精子-卵细胞不兼容性会影响IUI的结果.
- 在IUI重复失败的情况下,临床医生可能会考虑供体替代;进一步的前性研究是有必要的.
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