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排卵周期冷胚胎移植产生类似于计划移植的妊娠结果,同时避免痛苦的注射

Katie White¹, Jessica Cheung², Prachi Godiwala^2,3

¹Department of Obstetrics and Gynecology, Trinity Health of New England, Hartford, CT, USA.

Journal of assisted reproduction and genetics

|March 31, 2025

概括

排卵周期冷解胚胎移植 (Ovu-FET) 是40岁及以上的女性进行欧胚胎移植的安全有效选择,与编程周期FET (PC-FET) 相比,显示出类似的妊娠结果. 这支持老年患者的Ovu-FET.

科学领域:

生殖内分泌学生殖内分泌学
在体外受精过程中受精.
孕产妇和胎儿医学孕产妇和胎儿医学

背景情况:

最佳的子宫内膜准备对于成功的euploid胚胎移植至关重要.
排卵周期冷解胚胎转移 (Ovu-FET) 提供了潜在的好处,但在40岁以上的女性中尚未得到充分研究.
编程周期冷解胚胎移植 (PC-FET) 是一种替代方案.

研究的目的:

为了比较40-45岁的女性接受euploid胚胎移植的Ovu-FET和PC-FET之间的怀孕结果.
评估Ovu-FET在较老的生殖年龄组中的疗效和安全性.

主要方法:

对287个euploid胚胎移植周期 (2015-2022) 的回顾性队列研究.
对比了171个Ovu-FET循环与116个PC-FET循环.
使用多变量回归分析了正在进行的怀孕率,怀孕率,临床怀孕率和流产率.

主要成果:

持续怀孕率相似:62.6% (Ovu-FET) 与58.6% (PC-FET) 相比.
怀孕和临床怀孕率在各组之间没有显著差异.
临床损失率是可比的;生化损失率在Ovu-FET组略低 (7.6%vs14.7%).

结论:

对40岁及以上的女性进行卵子胚胎移植是可行的选择.
研究结果支持对老年生殖年龄患者使用Ovu-FET的信心增加.
在这个人群中,Ovu-FET和PC-FET之间的怀孕结果是可比的.

关键词:

年龄年龄年龄年龄年龄年龄宫内膜制备剂宫内膜制备剂在冷胚胎移植过程中,冷胚胎被移植.莱特醇FET的使用情况自然循环 FET 的自然循环排卵期FET的使用情况

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