心理药物多药会损害中风后患者的独立行走能力
Ayaka Matsumoto1, Yoshihiro Yoshimura2, Fumihiko Nagano2
1Center for Sarcopenia and Malnutrition Research, Kumamoto Rehabilitation Hospital, Kikuchi-County, 760 Magate, Kikuyo-Town, Kumamoto, 869-1106, Japan. ayk1224mtmt@gmail.com.
European journal of clinical pharmacology
|March 31, 2025
概括
在老年中风患者中,使用心理药物,特别是催眠药,与康复后走路独立性较差有关. 谨慎的药物管理对于改善这些个体的移动性至关重要.
科学领域:
- 老年医学 老年医学
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 精神药物在老年人中经常被使用,并且与不良结果有关.
- 有限证据表明,心理药物使用对中风后患者的行走能力的影响有限.
研究的目的:
- 为了研究精神药物使用与中风后患者的独立行走之间的联系.
主要方法:
- 559名正在接受康复的中风患者的回顾性队列研究.
- 在入院时记录的精神药物 (二,催眠药,抗精神药,抗抑郁药).
- 使用功能独立度量 (FIM) 步行得分 (≥6) 和后勤回归分析评估出院时的行走独立性.
主要成果:
- 25.4%的患者在入院时使用精神药物.
- 增加的精神药物数量独立地与较低的行走独立性相关 (OR 0.620,P=0.011).
- 催眠使用对行走独立性产生了显著的负面影响 (OR 0.331,P=0.004).
结论:
- 心理药物多药,特别是催眠药,在入院时与实现行走独立性中风后康复的可能性降低有关.
- 建议老年中风后患者谨慎使用心理药物,以实现行走目标.
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