最近出现糖尿病和新型糖尿病亚型的人群的黄斑 perfusion 改变
Sema Kaya1, Ala Khamees1, Gerd Geerling1
1Department of Ophthalmology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Diabetologia
|March 31, 2025
概括
在2型糖尿病中,早期的斑点毛细管变化在诊断时被检测出来,而长期存在的糖尿病会影响表面和深层毛细管. 光学连贯断层扫描血管造影揭示了早期的指标,如扩大的状血管区域和增加的流量缺陷,先于糖尿病视网膜病变.
科学领域:
- 眼科医生 眼科 眼科
- 糖尿病学 糖尿病学
- 医疗成像医学成像
背景情况:
- 糖尿病是一种全身性疾病,具有显著的眼部并发症.
- 早期检测视网膜中的微血管变化对于预防视力损失至关重要.
研究的目的:
- 在1型或2型糖尿病患者中使用光学连贯性断层扫描血管学 (OCTA) 检测黄斑毛细血管的早期结构和功能变化.
- 为了评估诊断后10年的变化.
主要方法:
- 一项横截面研究涉及143名1型糖尿病患者和197名2型糖尿病患者,以及105名对照参与者.
- 使用OCTA分析斑点毛细血管 perfusion 密度,血管密度,微动脉瘤,choriocapillaris 流量缺陷密度 (CC FD) 和状血管区域 (FAZ).
- 分析是在基线 (诊断后一年内) 和5年和10年间进行的.
主要成果:
- 2型糖尿病患者在基线时表现出表面毛细管 (SCP) perfusion 和血管密度的减少.
- 到第10年,1型和2型糖尿病都显示SCP和深毛细管 (DCP) 的 perfusion 密度降低.
- 在第一年内观察到扩大的FAZ和增加的CC FD,在2型糖尿病中更为明显. 微动脉瘤在5年出现,并与输液,血管密度和视网膜层厚度降低有关.
结论:
- 2型糖尿病会立即导致黄斑 perfusion 减少,而长期糖尿病会影响SCP和DCP.
- FAZ和CC FD是糖尿病微血管病变的早期指标,而2型糖尿病显示出更严重的变化.
- 微动脉瘤与视网膜内层稀薄相关,表明在明显的糖尿病视网膜病变或视力损伤之前存在亚临床的微血管损伤.
关键词:
一个叫做Choriocapillaris的小鱼儿.糖尿病亚型 糖尿病亚型糖尿病视网膜病变 - 糖尿病视网膜病变的非血管区是的非血管区.团结细胞层是团结细胞层.微动脉瘤是一种微动脉瘤.微血管病变是一种微血管病变.八国合作组织 (OCTA)perfusion 密度 perfusion 密度 输液密度 输液密度 输液密度 输液密度船舶密度 船舶密度 船舶密度更多相关视频
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