压力引起的大脑活动,心血管反应和中年成人亚临床动脉样硬化
Javier Rasero1,2, Timohy D Verstynen1, Caitlin M DuPont3
1Department of Psychology and Neuroscience Institute Carnegie Mellon University Pittsburgh PA USA.
Journal of the American Heart Association
|April 1, 2025
概括
心理压力会影响大脑活动和临床前动脉样硬化. 在压力期间的系统血压反应调解了这种联系,将大脑功能与中年成人血管健康联系起来.
科学领域:
- 神经科学是一个神经科学.
- 心血管科学 心血管科学
- 心理生理学 心理生理学
背景情况:
- 心理压力因素与临床前动脉样硬化和大脑活动模式有关.
- 之前的研究尚未确定心血管应激反应是否与个体内的大脑活动和动脉样硬化有关.
研究的目的:
- 为了调查压力引起的缩血压反应是否调解大脑活动和动脉动脉样硬化之间的关联.
- 在中年成人中使用交叉验证和预测建模来测试这种调解.
主要方法:
- 功能磁共振成像 (fMRI) 和缩血压 (SBP) 在信息冲突任务中测量了624名成年人.
- 动脉内心介质厚度 (CIMT) 通过超声波进行评估.
- 采用了一个调解框架,包括协调,交叉验证和处罚的主要组件回归.
主要成果:
- 跨大脑区域的任务平均fMRI活动显示出与CIMT的概括关联.
- 这种关联可靠地通过总体缩血压反应性来调节.
- 涉及的关键大脑区域包括腹中前额叶皮质,前带皮质,胰岛和杏仁体.
结论:
- 这些发现支持了压力引起的大脑活动和临床前动脉样硬化之间的联系.
- 压力引起的心血管反应的个体差异解释了这种联系.
更多相关视频
08:22Measuring Cardiac Autonomic Nervous System ANS Activity in Toddlers - Resting and Developmental Challenges
Published on: February 25, 2016
15.3K
04:20Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model
Published on: July 12, 2024
1.3K
相关概念视频
Psychoneuroimmunology: Cardiovascular Disease
23
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
23
Introduction to Stress and Lifestyle
62
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
62
Stress and Mental Health
68
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
68
The Sympathetic Nervous System
94.2K
Overview
94.2K
Exercise and Cardiovascular Response
687
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
687
Psychological Responses to Stress
34
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
34
