神经活动和癌症预后:系统性审查和元分析
Wen-Bo Huang1, Heng-Zhou Lai1, Jing Long1
1TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
BMC cancer
|April 1, 2025
概括
像SDNN和HF-HRV这样的心率变化 (HRV) 参数在癌症患者中显示出预后价值. 由HRV表示的神经 (VN) 活动升高,可能预测更长的生存期,但需要进一步的研究.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 自主神经系统研究 自主神经系统研究
背景情况:
- 在癌症患者中,通过心率变化 (HRV) 评估的阴道神经 (VN) 活动的预后作用受到争议.
- 这一元分析旨在澄清HRV指标与癌症预后之间的关联.
研究的目的:
- 在癌症患者中评估各种心率变化 (HRV) 参数的预后意义.
- 确定HRV是否可以预测癌症患者的整体存活率 (OS).
主要方法:
- 对11项涉及2539名参与者的队列研究进行了系统的元分析.
- 分析了来自PubMed,Embase,Cochrane和Web of Science的数据,重点关注整体生存时间 (OS) 的未调整危险比率 (HR).
- 采用随机或固定效应模型来计算聚合HR和95%信心区间 (CI),并对出版偏差进行漏斗图形分析.
主要成果:
- 较高标准偏差的正常到正常间隔 (SDNN) 是一个重要的保护因素,OS (HR=0.59,P<0.0001).
- 更高的高频功率HRV (HF-HRV) 和低频功率HRV (LF-HRV) 与显著更长的OS相关 (HR=0.59,P=0.006和HR=0.45,P=0.03,分别).
- 一些非线性HRV指数 (Lmax,Lmean,REC,DET) 表明OS较差,而RMSSD的预后值在统计学上并不显著.
结论:
- HRV参数,特别是SDNN和HF-HRV,证明了癌症预后的预测价值.
- 由HRV表明的神经 (VN) 活动升高,可能与延长生存结果相关.
- 由于研究异质性,研究结果需要谨慎解释;建议使用标准化协议的前性研究进行验证.
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