基线和预后营养指数的变化与心力衰竭住院和心脏起器患者的全因死亡有关
Jiayu Zhang1, Hongxia Yao2, Yingdan Lu1
1Department of Cardiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
BMC cardiovascular disorders
|April 1, 2025
概括
低预后营养指数 (PNI) 和随访期间PNI的下降预测心力衰竭患者的住院和死亡率. 这些发现强调PNI是心脏不良事件的关键指标.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 临床研究 临床研究
背景情况:
- 心脏起器患者面临心力衰竭住院和死亡的风险.
- 预后营养指数 (PNI) 是患者结果的潜在生物标志物.
研究的目的:
- 评估预后营养指数 (PNI) 水平和变化作为心力衰竭住院 (HFH) 和心脏起器患者死亡率的预测指标.
- 为了确定本患者队列中基线PNI和PNI变化的预后值.
主要方法:
- 在入院和1个月的随访期间计算PNI,并确定净变化 (ΔPNI).
- 根据最佳切割值,患者被分为高/低PNI组和改善/恶化PNI组.
- 考克斯的比例危险模型和受限立方线分析了PNI,ΔPNI和不良事件之间的关联.
主要成果:
- 低基线PNI与HFH和因任何原因死亡的风险显著增加有关 (调整后的HR分别为1.997和2.501).
- 在随访期间PNI下降 (ΔPNI ≤0) 预测高血压和死亡风险更高 (调整后HR分别为3.146和2.082).
- 在对其他风险因素进行调整后,这些关联仍然很重要.
结论:
- 低基线PNI是心脏起器患者高血压和死亡率的有效预测指标.
- 在1个月的随访期间PNI的下降也有效地预测了不良结果,包括HFH和死亡率.
- 在这个人群中,PNI作为一个有价值的预后指标.
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