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Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...

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Updated: May 16, 2025

Mechanical Stimulation of Stem Cells Using Cyclic Uniaxial Strain

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Published on: July 29, 2007

细胞机械记忆:一种潜在的工具,用于基于介质干细胞的疗法.

Sanjay Kumar Kureel¹, Rosario Maroto², Kristen Davis²

¹Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, 77555, USA. skkureel113@gmail.com.

Stem cell research & therapy

|April 1, 2025

概括

此摘要是机器生成的。

机械力显著影响细胞的行为和功能. 介质干细胞 (MSC) 中的细胞机械记忆 (CMM) 为基于细胞的疗法和疾病研究提供了一个有前途的目标.

关键词:

基于细胞的治疗方法纤维化纤维化纤维化机械记忆是一种机械记忆.机械刺激是一种机械刺激.介质细胞干细胞 (MSCs) 是一种干细胞.衰老是一种衰老.

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Published on: January 18, 2019

相关实验视频

Last Updated: May 16, 2025

Mechanical Stimulation of Stem Cells Using Cyclic Uniaxial Strain

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3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration

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科学领域:

生物医学工程生物医学工程
细胞生物学细胞生物学
机械生物学机械生物学

背景情况:

机械特性如刚性和流体流动影响细胞功能,影响组织特征和细胞表型.
细胞通过感知力,改变形状和适应功能来响应机械刺激,这对于组织平衡至关重要.
机械触发可以诱导细胞中的"记忆",影响细胞的可塑性和适应性.

研究的目的:

审查细胞机械记忆 (CMM) 在中皮系细胞中的作用.
探索CMM作为基于细胞治疗 (CBT) 的潜在治疗点.
突出CMM在癌症研究,纤维化和衰老方面的影响.

主要方法:

文献综述专注于机械生物学和细胞对机械刺激的反应.
对研究细胞机械记忆 (CMM) 在介质干细胞 (MSCs),纤维细胞和肌体细胞中的研究的分析.
综合了与机械因素对细胞表型和ECM重塑的影响有关的发现.

主要成果:

机械力,包括刚性,流动,负荷,压缩和拉伸,显然会影响细胞功能和表型.
细胞对机械变化的反应可以导致ECM的改变,增加组织硬性并影响功能.
细胞机械记忆 (CMM) 是一个关键的特征,使细胞能够适应和保留对机械刺激的反应.

结论:

细胞机械记忆 (CMM) 是细胞对机械线索的关键适应,特别明显在介质干细胞 (MSC) 中.
向CMM提出了一种新的策略,以应对基于细胞的治疗 (CBT) 的挑战,例如细胞稀缺.
了解CMM对于推进癌症,纤维化和衰老的研究至关重要,提供潜在的治疗途径.