基于数量的国家采购政策对治疗慢性骨髓性白血病的药物的影响
Zhao Yang1,2, Yiran Li3, Siyu Liu4
1Peking University First Hospital, Beijing, 100034, China. zhao.yang@bjmu.edu.cn.
Journal of health, population, and nutrition
|April 1, 2025
概括
中国国家基于体积的采购政策显著降低了铁氨酸激酶抑制剂伊马替尼的成本,增加了其在慢性髓性白血病患者中的使用. 这一政策改善了药物负担能力,并减少了CML患者的财务负担.
科学领域:
- 卫生经济学 卫生经济学
- 药物经济学 药物经济学
- 瘤学 治疗学 治疗学
背景情况:
- 氨酸激酶抑制剂 (TKIs) 对于慢性髓性白血病 (CML) 的生存至关重要,但成本昂贵.
- 高的TKI成本给CML患者带来了巨大的经济负担.
- 中国的全国量化采购 (NVBP) 政策旨在降低药品成本.
研究的目的:
- 评估中国的NVBP政策对TKI负担能力的影响.
- 评估采购量和NVBP后技术技能实施成本的变化.
- 分析NVBP政策对CML治疗的经济影响.
主要方法:
- 利用来自中国医疗保险局的药品采购交易数据.
- 从2019年1月到2020年12月,分析了25个省份的伊马替尼,尼洛替尼和达沙替尼数据.
- 采用中断时间序列模型来评估政策对负担能力,DDD,支出和DDDc的影响.
主要成果:
- 在NVBP政策下降了Imatinib的单位价格,提高了可负担性和DDDs146.9万.
- 获胜投标的仿制药伊马替尼的采购量激增,其使用份额从40%上升到80%.
- 伊马替尼的DDDc下降了69.5,在赢得竞标和非竞标的仿制药中都有显著下降.
结论:
- 该NVBP政策有效降低了药品价格,并促进了相关技术知识的利用.
- 该政策改善了接受长期治疗的CML患者的药物负担能力.
- 实施NVBP减少了与必要的CML疗法相关的财务负担.
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