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潜在类分析在新诊断的全身性青少年异常性关节炎中确定了不同的疼痛表型

Hui Zhang¹, Xiaoqiong Wei², Wei Liu³

¹Department of Nursing, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, China.

Arthritis research & therapy

|April 1, 2025

概括

系统性青少年异常性关节炎 (sJIA) 疼痛呈现出三种不同的表型,受年龄和IL-10水平的影响. 识别这些疼痛模式有助于为sJIA患者制定个性化治疗策略.

科学领域:

类风湿病学类风湿病学
儿科风湿病学儿科风湿病学
疼痛医学医学疼痛医学

背景情况:

系统性青春性异常性关节炎 (sJIA) 会引起各种疼痛症状,影响生活质量.
了解sJIA疼痛表型及其驱动因素是定制疼痛管理的关键.
在sJIA中,异质的疼痛表现需要详细的表型来进行有效的治疗.

研究的目的:

通过隐性类分析 (LCA) 将sJIA疼痛表型分类.
确定影响这些疼痛表型的因素.
评估疼痛表型对sJIA患者短期住院治疗结果的影响.

主要方法:

对165名新诊断的sJIA患者进行了回顾性队列研究.
隐性类分析 (LCA) 用于疼痛表型识别.
多变量逻辑回归和Lanza-Tan-Bray方法用于因子和结果分析.

主要成果:

确定了三种SJIA疼痛表型: 1) 中度至重度疼痛与功能障碍 (53.9%), 2) 轻度间歇性疼痛与关节外症状 (19.4%), 3) 没有关节疼痛与轻度障碍 (26.7%).
年龄和血清IL-10水平显著影响了疼痛表型 (P<0.05).
在表型之间观察到住院,部门转移和出院疼痛状态的显著差异.

结论:

脑脊髓炎疼痛可以分为三个不同的表型.
年龄和IL-10水平是SJIA疼痛表型的重要影响因素.
现型鉴定对于在sJIA中开发个性化疼痛管理策略至关重要.

关键词:

电子健康记录是电子健康记录.在 IL-10 中,IL-10 是 IL-10 的代表.隐藏类分析隐藏类分析疼痛的现象型疼痛的现象型系统性青少年异常性关节炎

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