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Updated: May 16, 2025

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TNFAIP8L2维持毛细胞功能,并通过mTORC1信号传递调节与年龄相关的听力损失

Wen Li1, Yu Li1, Min Wang1

  • 1School of Clinical and Basic Medical Sciences, Shandong Provincial Hospital, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China.

Molecular therapy : the journal of the American Society of Gene Therapy
|April 1, 2025
PubMed
概括

瘤缩因子-α诱导蛋白-8-like 2 (TNFAIP8L2) 缺乏症通过激活mTORC1信号,导致与年龄相关的听力损失. 用拉巴胺素抑制这种途径或准RHEB/RAC1显示出对听力退化有治疗潜力.

关键词:
这是ARHLHL.雷伯 (RHEBEB) 是一个名字.在TNFAIP8L2中使用.头发细胞是指毛细胞.在 mTORC1 的情况下,mTORC1 是

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