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使用新型咨询小组方法优化数学人口癌症流行病学模型的面部有效性和临床相关性
Louise Davies1,2, Sara Fernandes-Taylor3, Natalia Arroyo4
1Department of Veterans Affairs Medical Center, The VA Outcomes Group, White River Junction, VT, USA.
概括
这项研究通过结合专家和患者的投入,开发了一种针对乳头甲状腺癌 (PATCAM) 的癌症模拟模型. 这种方法提高了模型的准确性和政策决策的临床相关性.
科学领域:
- 在瘤学瘤学.
- 医疗保健服务研究 医疗服务研究
- 计算生物学 计算生物学
背景情况:
- 在未来数据有限的情况下,癌症模拟模型对研究和政策有价值.
- 挑战包括结合不可测量的输入,并确保临床相关性和面部有效性.
- 开发乳头甲状腺癌微显模拟模型 (PATCAM) 需要解决这些有效性挑战.
研究的目的:
- 系统地将正式的咨询意见纳入癌症微型模拟模型的开发中.
- 为了提高PATCAM模型的面部有效性和临床相关性.
- 为了减轻与癌症建模中不可测量的输入相关的挑战.
主要方法:
- 采用参与式行动研究方法,使用焦点小组技术和双向学习.
- 建立了一个正式的,常设的咨询小组,拥有多样化的代表 (医疗,患者,付款人).
- 利用咨询小组为有关诊断,治疗和流行病学的关键建模假设提供信息.
主要成果:
- 咨询小组提供了关于结节大小,活检趋势,特种变异,癌症患病率,瘤回归和性别/年龄特定流行病学的重要意见.
- 纳入咨询投入增加了PATCAM模型的面部有效性和透明度.
- 咨询小组的反确定了未来的研究问题,并改进了传播策略.
结论:
- 使用常设咨询小组的参与式建模方法成功提高了乳头甲状腺癌显微模拟模型的有效性和相关性.
- 这种方法通过与主题专家严格审查假设来加强癌症模型.
- 该方法促进透明度,有助于传播,并为未来的研究提供信息,以最大限度地影响临床决策和政策.
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