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饮酒动机和酒精敏感性介导多维遗传影响酒精使用行为

Jeanne E Savage¹, , Danielle M Dick²

¹Department of Complex Trait Genetics, Centre for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam, The Netherlands.

Alcohol, clinical & experimental research

|April 1, 2025

概括

遗传因素影响酒精使用行为 (AUBs),中间特征如饮酒动机和酒精敏感性部分介导这些影响. 了解这些途径可以为AUBs提供基因研究和干预信息.

科学领域:

行为遗传学行为遗传学
神经科学是一个神经科学.
精神病学是一个精神病学.

背景情况:

遗传因素对酒精使用行为 (AUB) 的个体差异有显著的贡献.
现有的研究确定了与各种AUB相关的多个基因组,但因果途径仍然不清楚.
了解对AUBs遗传影响的神经生物学媒介对于破译复杂的遗传特征至关重要.

研究的目的:

调查中介神经生物学特征是否调解多基因分数 (PGS) 和多个AUB之间的关系.
阐明与饮酒相关的不同遗传特征背后的过程.
通过检查基因与酒精使用关系中的调解因素来确定潜在的干预目标.

主要方法:

四个与酒精相关的PGS来自Spit for Science纵向研究 (n=4549).
使用线性回归来评估PGS与22个潜在介质 (例如人格,期望,动机,敏感性) 之间的关联.
多种调解模型估计了对四种AUB的直接和间接影响:频率,数量,酒精使用障碍症状 (AUDsx) 和最大饮料.

主要成果:

每周饮料 (DPW) 和问题性酒精使用 (PAU) 的PGS与更高的冲动性,饮酒动机和较低的酒精敏感性有关.
BeerPref PGS与更高的负面紧迫性和较低的酒精敏感性有关.
调解分析显示,DPW PGS通过社会/增强动机和酒精敏感性影响了AUB;PAU PGS间接影响了AUDsx;BeerPref PGS通过包括酒精敏感性在内的调解者影响了饮酒频率和AUDsx.

结论:

对AUBs的遗传影响部分由中介的神经生物学和认知因素介导,例如饮酒动机和酒精敏感性.
这些调解因素可能代表干预的目标.
未来的遗传研究应该专注于将基因与酒精使用结果联系起来的异质途径,强调饮酒动机和酒精敏感性.

关键词:

饮酒的动机是喝酒的动机.遗传异质性的遗传异质性对酒精反应的水平.调解调解是指调解的方式.多基因分数的多基因分数

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