在胰岛素瘤相关的低血糖症中Pasireotide的有效性和安全性:系统性审查
Arturo Vega-Beyhart1, Betina Biagetti2, Mónica Marazuela3
1Endocrinology and Nutrition department, Hospital Universitario Ramón y Cajal, Madrid Spain.
The Journal of clinical endocrinology and metabolism
|April 1, 2025
概括
帕西雷奥提德有效地控制了对其他治疗无反应的患者的胰岛素瘤相关低血糖症. 在侵袭性瘤中有效性降低,这表明早期使用或组合疗法可能会改善结果.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 持续性低血糖是胰岛素瘤患者的一个关键并发症.
- 手术切除瘤并不总是可行的,这使得医疗管理至关重要.
- 帕西雷奥提德显示可能导致耐药性低血糖症,但缺乏广泛的临床数据.
研究的目的:
- 系统地审查Pasireotide在治疗与胰岛素瘤相关的低血糖症中的疗效和安全性.
- 根据瘤特征和患者因素评估治疗结果.
主要方法:
- 通过使用多个数据库 (MEDLINE,Scopus,Google Scholar) 进行了系统的文献审查.
- 搜索覆盖了数据库开始至2024年3月30日,包括前向和后向引用检查.
- 纳入标准侧重于报告帕西雷奥提德用于胰岛素瘤相关低血糖症的研究.
主要成果:
- 13项研究中的17个案例符合纳入标准.
- 低血糖症在41%的患者中完全消失,23%的患者出现部分改善,35%的患者没有改善.
- 侵袭性胰岛素瘤和较大的瘤与显著较低的应答率有关. 高血糖是最常见的副作用.
结论:
- 帕西雷奥提德有效地恢复胰岛素瘤患者的葡萄糖水平,这些患者患有耐治疗低血糖症.
- 在侵袭性胰岛素瘤中,疗效降低,突显了需要替代或组合策略的需要.
- 选择的患者早些时候服用帕西雷奥提德可能会提高治疗结果.
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