血乙酸水平与美国成年人睡眠投诉之间的非线性关联:NHANES 2009-2010年
1Endoscopy Center, Jinshan Hospital, Fudan University, Shanghai, China.
Lipids
|April 1, 2025
概括
睡眠不足是一个日益严重的公共卫生问题. 这项研究发现,高水平的反式脂肪酸 (TFAs),特别是酸,与美国成年人睡眠问题增加有关.
科学领域:
- 营养科学 营养科学
- 睡眠医学 睡眠医学
- 公共卫生 公共卫生
背景情况:
- 睡眠不足与许多慢性疾病有关,包括代谢,心血管,精神和神经退行性疾病.
- 众所周知,反式脂肪酸 (TFAs) 对健康有有害影响,但它们对睡眠结果的具体影响尚不清楚.
- 酸是主要的TFA,了解它与睡眠的关系对于公共健康至关重要.
研究的目的:
- 在美国成年人群中调查血乙烯酸水平和自我报告的睡眠投诉之间的联系.
- 确定这种关联是线性的还是非线性的,并确定任何潜在的值.
- 评估各种人口分组的调查结果的可靠性.
主要方法:
- 利用了2009-2010年美国国家健康和营养检查调查 (NHANES) 的数据.
- 使用气体染色学/质谱法 (GC/MS) 测量了血中乙烯酸度.
- 根据医生诊断的睡眠困难或睡眠障碍的问卷答复定义了睡眠抱怨;使用多变量逻辑回归和受限立方脊柱 (RCS) 分析分析了分析的关联.
主要成果:
- 总共有2068名参与者被分析,其中561人报告睡眠投诉.
- RCS分析显示了血乙烯酸和睡眠投诉之间的非线性,反转的L形关系 (p=0.044),曲点为9.598μmol/L.
- 在低于这个值 (OR 1.28;95% CI:1.06 - 1.54,p=0.01) 的血乙酸水平和睡眠抱怨之间观察到积极的关联,但不超过它. 调查结果在人口结构层面上是一致的.
结论:
- 血乙酸水平升高,特别是低于9.598μmol/L,与美国成年人睡眠投诉的患病率增加有关.
- 这些发现表明,酸可能会对睡眠质量产生负面影响,尽管TFA摄入量下降,但需要进一步关注.
- 需要进一步的研究来阐明TFA和睡眠障碍之间的关系背后的机制.
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