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Updated: May 16, 2025

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats
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基努伦酸和促进依赖活动的突触消除在精神分裂症

Funda Orhan1, Susmita Malwade1, Neda Khanlarkhani1

  • 1Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm (Orhan, Malwade, Khanlarkhani, Gkogka, Jungholm, Koskuvi, Schwieler, Jardemark, Erhardt, Engberg, Samudyata, Sellgren); Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm (Langeder); Neuroscience Center, HiLIFE, University of Helsinki, Helsinki (Koskuvi, Lehtonen, Tiihonen, Koistinaho); A.I. Virtanen Institute for Molecular Sciences (Lehtonen) and Department of Forensic Psychiatry (Tiihonen), University of Eastern Finland, Kuopio; Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, and Stockholm Health Care Services, Stockholm County Council, Stockholm (Tiihonen, Sellgren); Institute of Sport Science and Innovations, Lithuanian Sports University, Kaunas, Lithuania (Engberg).

The American journal of psychiatry
|April 1, 2025
PubMed
概括

在精神分裂症中,高氨酸 (KYNA) 驱使微质细胞吞突触. 抑制KYNA的产生可能会在这种神经发育障碍中防止突触损失.

关键词:
质细胞 质细胞诱导的多能干细胞干细胞精神分裂症是一种精神分裂症.突触消除 突触消除三甲的新陈代谢

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