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三甲胺减轻甲基酸诱导的肝损伤:从生物化学,组织学和体分析的见解

Maha R A Abdollah^1,2, Mohamed H Aly^1,2, Maha E Wally^1,2

¹Department of Pharmacology, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.

Archiv der Pharmazie

|April 1, 2025

概括

通过改善氧化应激,炎症和亡标志物,三甲素 (TMZ) 前期治疗显著减少了大鼠中甲甲酸盐 (MTX) 诱导的肝损伤. 这表明TMZ.

科学领域:

肝病学肝病学是一种肝病学.
药理学药理学是指药理学的学科.
毒理学毒理学毒理学

背景情况:

甲甲酸 (MTX) 是一种已知具有肝毒性的化疗剂.
三甲素 (TMZ) 是一种抗缺血药物,具有潜在的细胞保护性.

研究的目的:

为了研究重定向三甲 (TMZ) 对甲基 (MTX) 诱导的肝毒性的疗效.
为TMZ在MTX引起的肝损伤中的保护作用提供初步证据.

主要方法:

在MTX (30 mg/kg) 给药之前,老鼠接受了TMZ (20 mg/kg) 的预治疗.
评估了血清中氨基酶,氧化应激标记物 (GSH,MDA),炎症标记物 (NF-κB),抗氧化剂标记物 (Nrf2,HO-1),ATP水平和亡标记物 (Bax/BCL2比率,caspase-3).
对TMZ目标进行了路丰富分析 (PEA).

主要成果:

TMZ预治疗显著降低了MTX诱导的血清透氨酶和MDA的升高.
TMZ预治疗恢复了GSH水平,并增加了Nrf2,HO-1和ATP水平.
TMZ预治疗降低了NF-κB (p65) 水平和Bax/BCL2比率和caspase-3活性,表明炎症和亡减少.
在分析中发现TMZ途径与氧化应激,炎症和亡有关.

结论:

在大鼠模型中,三甲丁 (TMZ) 有效地改善了甲醇 (MTX) 诱导的肝毒性.
TMZ通过减轻氧化应激,炎症和亡来证明细胞保护作用.
TMZ对MTX诱导的肝损伤的治疗潜力需要进一步研究.

关键词:

在 NF-κBB 中.肝毒性肝毒性肝毒性在的中.甲基特雷克萨酸盐的使用方法三甲胺的使用方法

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