移植的ABC:ALAD,BLAD和CLAD:定义和意义
Geert M Verleden1, Saskia Bos2
1Department of Respiratory Disease and Lung Transplantation, Antwerp University Hospital, Edegem.
Current opinion in pulmonary medicine
|April 1, 2025
概括
新的术语如急性肺异位移植功能障碍 (ALAD) 和基线肺异位移植功能障碍 (BLAD) 需要更清晰的定义. 本综述阐明了它们对肺移植接受者的意义和影响.
科学领域:
- 移植免疫学 移植免疫学
- 肺部医学 肺部医学
- 所有的移植研究.
背景情况:
- 慢性肺异位移植功能障碍 (CLAD) 是肺移植后的一个已知的并发症.
- 现有的CLAD表型化方法存在挑战.
- 新兴的术语,急性肺异位移植功能障碍 (ALAD) 和基线肺异位移植功能障碍 (BLAD),缺乏确定的定义和意义.
研究的目的:
- 定义急性肺异位移植功能障碍 (ALAD) 和基线肺异位移植功能障碍 (BLAD).
- 总结目前对与ALAD和BLAD相关的结果的理解.
- 讨论慢性肺部全移植功能障碍 (CLAD) 现有表型化挑战.
主要方法:
- 对现有关于肺异位移植功能障碍的研究进行文献综述.
- 在国际心脏和肺移植协会 (ISHLT) 的高级肺衰竭和移植跨学科网络 (ALFTx IDN) 内的专家小组讨论.
主要成果:
- 介绍了目前的ALAD和BLAD的定义,患病率和结果.
- 承认现有的不确定性和围绕这些新实体的持续讨论.
- 突出了CLAD的表型化中持续存在的陷.
结论:
- 为 ALAD 和 BLAD 提供了明确的定义.
- 总结了这些条件的确定的结果.
- 解决了CLAD表型化方面的挑战,以改善肺移植护理.
相关概念视频
Tissue Transplantation
299
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
299
Bone Marrow Sampling and Transplants
266
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
266
Blood Transfusion and Agglutination
10.6K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.6K
Cell-mediated Immune Responses
66.4K
Overview
66.4K


