用于预测口腔状细胞癌的整体存活率的一种名谱:一个SEER数据库和外部验证研究
Ziye Xu1, Manbin Xu1, Zhichen Sun2
1Department of Head and Neck Surgery, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Frontiers in oncology
|April 1, 2025
概括
一个新的诺米图准确地预测了口腔状细胞癌 (OSCC) 患者的整体存活率 (OS). 这种工具有助于临床医生做出个性化治疗决策,并改善患者管理,以获得更好的结果.
科学领域:
- 在瘤学瘤学.
- 癌症预后 癌症预后
- 生物统计学 生物统计学
背景情况:
- 口腔状细胞癌 (OSCC) 与低生存率有关,特别是在晚期.
- 准确的预后工具对于OSCC中有效的患者管理和治疗计划至关重要.
研究的目的:
- 开发和验证用于预测口腔状细胞癌 (OSCC) 患者的整体存活率 (OS) 的名图.
- 纳入人口,临床病理和治疗因素,以提高预测准确度.
主要方法:
- 来自美国数据库的15204名OSCC患者的回顾性分析,以构建预后模型.
- 外部验证使用来自中国癌症中心的359名OSCC患者队列.
- 考克斯回归分析以确定预后因素,通过C指数,AUC,校准和决策曲线分析评估模型性能.
主要成果:
- 确定的主要独立预后因素包括年龄,性别,原发性瘤部位,T和N阶段,以及治疗方式.
- 该名图显示C指数为0.727 (培训) 和0.6845 (验证),表现优于TNM分阶段系统.
- 通过AUC和决策曲线分析证实了卓越的预测准确性,校准和临床效用,并进行了有效的风险分层.
结论:
- 开发出来的名图表可以作为一个有效的,个性化的工具来预测OS在OSCC中的OS.
- 该工具帮助临床医生做出明智的治疗决策,并优化患者管理策略.
- 诺米图有助于改善OSCC患者的预后评估和风险分层.
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