骨质疏松症和全身血管骨折:一个系统性审查和元分析
Angelo Fassio1, Alvise Berti2,3, Alessandro Mantovani4
1Rheumatology Unit, University of Verona, Verona, Italy.
Frontiers in immunology
|April 1, 2025
概括
系统性血管 (SVs) 显著增加骨质疏松症和骨折的风险. 患有SVs的患者患上这些疾病的患病率更高,需要警监测和早期查.
科学领域:
- 类风湿病学 类风湿病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 系统性血管病 (SVs) 是一组罕见疾病,其特征是血管炎症.
- 骨质疏松症和脆弱性骨折是严重的健康问题,特别是在慢性炎症条件下.
- 与一般人群相比,SV患者的骨质疏松症和骨折的患病率和风险需要彻底调查.
研究的目的:
- 系统地审查和分析有关骨质疏松症和骨质疏松性骨折在SVs患者中患病率的观察性研究.
- 为了确定与健康对照组相比,SV患者的骨质疏松症和骨质疏松性骨折风险.
- 探索与SV患者骨质疏松风险相关的因素.
主要方法:
- 在2024年2月之前对Scopus,Web of Science和PubMed进行系统的文献搜索.
- 来自40项观察性研究的数据的元分析,其中包括23358名SV患者.
- 骨质疏松症和骨折的几率比率 (ORs) 的计算,以及相关因素的元回归.
主要成果:
- 在SV患者中,骨质疏松症的患病率为14.64%,脆弱性骨折的患病率为17.08%.
- 与对照人群相比,SV患者的骨质疏松症 (OR=2.92) 和脆弱性骨折 (OR=2.39) 的风险明显更高.
- 累积的葡萄糖皮质醇剂量与患有骨质疏松症的风险增加有关.
结论:
- 系统性血管酸与骨质疏松症和脆弱性骨折的风险大大增加有关.
- 建议对SVs患者进行主动监测和早期骨质疏松症查.
- 葡萄糖皮质激素治疗是导致骨质疏松症的重要危险因素.
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