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Updated: May 16, 2025

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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通过个性化抗原不可知查方法识别的T细胞受体准了共享的新抗原KRAS Q61H

Volker Lennerz1,2,3, Christoph Doppler1, Martina Fatho1

  • 1Internal Medicine III, University Medical Center (UMC) of the Johannes Gutenberg University Mainz, Mainz, Germany.

Frontiers in immunology
|April 1, 2025
PubMed
概括

这项研究引入了一种新的方法,用于在固体癌症中确定瘤特异性T细胞受体 (TCR) 用于采用细胞疗法 (ACT). 这种抗原无定性方法可以为更多患者推进TCR工程T细胞疗法.

关键词:
在KRAS Q61H中使用.T细胞受体 (TCR) 是一种T细胞受体.在TCR-T细胞中.癌症免疫疗法免疫疗法免疫瘤学 免疫瘤学新抗原是一种新抗原.致癌驱动基因 - - 致癌驱动基因针对瘤的特定抗原.

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