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Updated: May 16, 2025

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
11:34

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers

Published on: December 5, 2017

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在HER2接口中的热点突变会破坏结构的稳定,导致乳腺癌治疗失败

Abhijit De1, Pranay Dey, Aniketh Bishnu

  • 1Advanced Centre for Treatment Research & Education in Cancer.

Research square
|April 1, 2025
PubMed
概括

在二分化域II和IV中的新HER2突变导致对常见的乳腺癌疗法如trastuzumab产生抗性. 这些发现突出了HER2阳性乳腺癌中潜在的新治疗点和抵抗机制.

关键词:
在HER2阳性患者中,HER2是阳性的.乳腺癌 乳腺癌 乳腺癌分化域突变 变异域突变热点突变 热点突变在这种情况下,neratinib.这就是特拉斯图祖马布 (trastuzumab).治疗抵抗性的治疗.

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