阻塞性睡眠呼吸暂停和多种不良临床结果之间的关联:来自雨审查的证据
Qian Wang1, Hong Zeng1, Jindong Dai1
1Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Frontiers in medicine
|April 1, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 与许多不良健康结果有关,包括某些癌症的风险增加,GERD,心房动,骨质疏松症和糖尿病. 这些关联的证据质量通常很低.
科学领域:
- 睡眠医学 睡眠医学
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 意识正在增加,已确定与不良临床结果相关的病例.
- 现有研究表明,OSA与各种负面健康后果之间存在重大关联.
研究的目的:
- 进行综合性审查,总结和评估OSA和多种不良临床结果之间的关系的证据.
- 综合现有关于OSA及其临床影响的元分析的发现.
主要方法:
- 在PubMed,Embase和Web of Science数据库中进行系统搜索,直到2023年9月.
- 使用AMSTAR和GRADE标准对元分析质量的评估.
- 使用随机或固定效应模型和95%置信区间 (CI) 评估OSA相关结果的效应大小.
主要成果:
- 包括27个元分析,涵盖43个不良临床结果.
- 在OSA和甲状腺癌 (HR=2.32),癌 (RR=1.81),肝癌 (RR=1.19),GERD (OR=1.53),心房动 (OR=2.54),骨质疏松症 (OR=2.03) 和糖尿病 (OR=1.40) 之间发现了显著的关联.
- 由AMSTAR和GRADE评估的包含的元分析的整体质量通常很低.
结论:
- 阻塞性睡眠呼吸暂停 (OSA) 与一系列不良临床结果有显著的关联.
- 该审查强调,在患有OSA的人群中,某些恶性瘤和其他疾病的风险增加.
- 一些不良结果与OSA严重程度有密切的关系.
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