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在长期流量下,自我组装的微血管网络的改造
Marie Floryan1, Elena Cambria2, Adriana Blazeski1
1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
bioRxiv : the preprint server for biology
|April 1, 2025
概括
微生理系统 (MPS) 中的连续流恢复并维持可 perfusable 微血管网络 (MVNs) 超过51天. 这种流动促进血管重塑,减少炎症,并使长期疾病的建模成为可能.
科学领域:
- 生物医学工程 生物医学工程
- 微流体学 微流体学
- 芯片上的器官技术
背景情况:
- perfusion 和微血管网络 (MVNs) 对器官芯片模型至关重要.
- 对于器官成熟,疾病建模和研究运输现象,需要长期输液.
研究的目的:
- 在微生理系统 (MPS) 中研究连续流对微血管网络的长期影响.
- 评估MPS在模拟血液动力学驱动过程和慢性疾病方面的潜力.
主要方法:
- 使用微生理系统,持续 perfusion 的微血管网络.
- 采用计算建模来分析流动力学.
- 进行细胞因子分析以评估炎症.
- 进行大量RNA测序以确定细胞反应.
主要成果:
- 连续流在回归的MVN中恢复了输液,并保持了至少51天.
- 改造MVN以与流动方向保持一致,通过特定的维护介质达到平衡.
- 流量减少了炎症,并随着时间的推移降低了血管抵抗力.
- 内皮细胞和纤维细胞在响应流动时表现出活跃的重塑,效果持续数周.
结论:
- 这种MPS支持MVN的长期输液和重塑,这对于先进的器官芯片应用至关重要.
- 该系统适用于研究药物分发,转移和慢性炎症或与衰老相关的疾病等过程.
关键词:
流动 流动 流动 流动这是一种炎症炎症炎症炎症.微生理系统的微生理系统.微血管网络是微血管网络.perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion 这是一个非常重要的方法,它可以让一个人觉得自己是个好的人,而不是一个好的人,而是一个好的人.收回回收回收的恢复改造 改造 改造 改造 改造 改造
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