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Updated: May 16, 2025

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GMCL1 控制53BP1的稳定性,调节癌症中帕克利塔塞尔敏感性

Yuki Kito1,2, Tania J Gonza Lez-Robles1,3,4, Sharon Kaisari1,2,4

  • 1Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA.

bioRxiv : the preprint server for biology
|April 1, 2025
PubMed
概括

高GMCL1表达通过降解53BP1驱动癌症中帕克利塔塞尔耐药性,防止线粒体计时器复合体的形成,促进细胞增殖. 抑制GMCL1可能会恢复分类体的敏感性.

关键词:
53BP1BP1是什么意思GMCL1 GMCL1 的使用方法线粒体的时间表是线粒体的时间表.在p53中,p53是什么?长时间的线粒分裂.蛋白质降解 蛋白质降解在任何地方都是无处不在的.

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