条件恐惧的关联编码在体核团聚在动物和人类
Tuğçe Tuna1,2, Michael S Totty3, Muhammad Badarnee4
1Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX.
bioRxiv : the preprint server for biology
|April 1, 2025
概括
核团聚 (RE) 调节情感记忆和恐惧抑制. 人类和老鼠的RE活动反映了学会的恐惧关联和防御行为,这表明它在情绪处理中起着保留的作用.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 认知神经科学 认知神经科学
背景情况:
- 核团聚 (RE),一个中线的乳头结构,连接中间前额叶皮质 (mPFC) 和海马体 (HPC).
- 新出现的证据表明,RE参与调节情绪记忆,特别是恐惧抑制.
- 在RE中潜在的厌恶性学习和记忆的神经机制在物种之间仍然基本上没有特征.
研究的目的:
- 研究核团聚 (RE) 中厌恶性学习和情感记忆处理的神经相关性.
- 检查RE在动物和人类恐惧调节和灭绝中的保存功能.
主要方法:
- 在帕夫洛夫恐惧调节和灭绝范式期间,在人类中利用了BOLD fMRI和在老鼠中使用纤维光度.
- 在老鼠中进行单单元记录,以分析与关联学习和防御行为相关的神经元活动.
- 研究了受条件刺激 (CS) 唤起的活动和RE内的自发神经活动.
主要成果:
- 在这两种物种中,受条件刺激 (CS) 引起的RE活性与CS的关联值相关.
- 在老鼠中,自发的RE神经活动跟踪了防御性结行为,预期增加之前的结终止.
- 在RE中确定了不同的神经元组合来编码恐惧和灭绝记忆,个别的RE神经元索引了CS关联值和行为过渡.
结论:
- 核团聚 (RE) 在调节防御状态和情绪记忆过程中,在各个物种中发挥着保留作用.
- RE神经活动反映了条件刺激的关联价值,并参与了恐惧和灭绝记忆的调节.
- 这些发现为通过阐明RE在情绪记忆调节中的功能,为对恐惧相关疾病的翻译研究提供了基础.
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