相关实验视频

Updated: May 16, 2025

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Published on: April 29, 2022

在老年小鼠中,日常调节尿路行为和基因表达

Danielle S Taylor^1,2, Albert A Allotey², Rachel E Fanelli^1,3

¹Department of Zoology and Physiology, University of Wyoming, Laramie WY.

bioRxiv : the preprint server for biology

|April 1, 2025

概括

衰老会扰乱身体的内部时钟,导致夜尿症 (夜间经常排尿). 这项研究确定了膀Piezo1通道的昼夜调节受损是与年龄相关的夜的关键因素.

科学领域:

老年学是一门学科.
时间生物学时间生物学
泌尿器科泌尿器科泌尿器科泌尿器科

背景情况:

夜尿,或醒来排尿,在老年人中很常见,但不太了解.
现有的临床前模型很少用于研究与年龄相关的夜机制.

研究的目的:

开发一种翻译性小鼠模型,用于研究与年龄相关的夜.
调查老年人夜尿症背后的病理生理机制.

主要方法:

在老年小鼠中开发了一种行为范式,以评估昼夜尿路模式.
对老年和成年小鼠的和膀组织进行了分子分析.
检查了昼间基因和Piezo1通道的日间表达.

主要成果:

与对照组相比,老年小鼠表现出尿路行为的日间调节减弱.
在老老鼠的脏和膀中观察到昼夜基因的表达受损.
确定了与年龄相关的白天Piezo1通道调节损失,将昼夜干扰与膀敏感性联系起来.

结论:

循环功能障碍在与年龄相关的夜中起着重要作用.
膀机械感知离子通道Piezo1是夜干预的潜在治疗点.

更多相关视频

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

Published on: January 20, 2015

Evaluating the Procedure for Performing Awake Cystometry in a Mouse Model

Evaluating the Procedure for Performing Awake Cystometry in a Mouse Model

Published on: May 20, 2017

相关概念视频

Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...