相关实验视频

Updated: May 16, 2025

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines
10:46

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines

Published on: June 2, 2018

9.2K

基因组语言模型用于预测增强剂及其在人类基因组中的等位基因特异性活动

Rekha Sathian, Pratik Dutta, Ferhat Ay

    bioRxiv : the preprint server for biology
    |April 1, 2025
    PubMed
    概括

    DNABERT-Enhancer使用基因组语言模型准确预测称为增强剂的调节元素,改进了以前的方法. 该工具有助于理解基因调节,并识别与疾病相关的遗传变异.

    更多相关视频

    Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations11:36

    Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

    Published on: April 21, 2023

    1.9K
    Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation09:07

    Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation

    Published on: June 21, 2016

    8.1K

    相关概念视频

    Genomic DNA in Eukaryotes00:58

    Genomic DNA in Eukaryotes

    Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
    46.6K
    Chromatin Position Affects Gene Expression02:35

    Chromatin Position Affects Gene Expression

    Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
    Topologically Associated Domains (TADs)
    The 3-dimensional positioning of chromatin in the nucleus influences the...
    23.2K
    Cell Specific Gene Expression01:58

    Cell Specific Gene Expression

    Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
    13.3K
    Genome-wide Association Studies-GWAS01:11

    Genome-wide Association Studies-GWAS

    Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
    GWAS does not require the identification of the target gene involved in...
    12.2K
    Organization of Genes02:07

    Organization of Genes

    Overview
    68.2K
    Epigenetic Regulation01:37

    Epigenetic Regulation

    Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
    X-chromosome...
    3.0K