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Updated: May 16, 2025

Pentylenetetrazole-Induced Kindling Mouse Model
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Published on: June 12, 2018

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以前的表观遗传状态预测了小鼠未来对发作的易感性

Benjamin D Boros1, Mariam A Gachechiladze2,3, Juanru Guo2

  • 1Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.

bioRxiv : the preprint server for biology
|April 1, 2025
PubMed
概括

随机表观遗传变异影响神经发育,可以预测小鼠的发作严重程度. 这项研究使用呼叫卡将表观遗传变化与特定的基因功能联系起来,为神经精神疾病提供了洞察力.

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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