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在2型糖尿病中对高血糖/低血糖的感知及其相关因素:基于持续血糖监测的前性观察性研究
Yuka Suzuki1, Aika Miya1, Akinobu Nakamura1
1Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638 Japan.
Diabetology international
|April 1, 2025
概括
许多糖尿病患者低估了高或低血糖水平,影响了血糖控制. 高龄和不使用胰岛素与这种感知差距有关,凸显了对个性化护理的需求.
科学领域:
- 内分泌学 在内分泌学.
- 糖尿病管理 糖尿病管理
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 有效的糖尿病管理需要对高血糖和低血糖的准确感知.
- 无法识别或低估葡萄糖游览可能会阻碍最佳的血糖控制.
- 这项研究解决了2型糖尿病患者感知和客观测量的葡萄糖水平之间的差距.
研究的目的:
- 调查2型糖尿病患者,尽管他们意识到高血糖或低血糖是有问题的,但他们可能不会认为高血糖或低血糖是有问题的.
- 确定导致自我报告的感知和客观葡萄糖测量之间的差异的因素.
- 分析与无法感知高血糖或低血糖相关的临床特征.
主要方法:
- 对284名患有2型糖尿病的日本人进行前性观察研究.
- 使用了门诊盲目专业连续血糖监测 (CGM).
- 糖尿病治疗满意度问卷 (DTSQ) 用于评估葡萄糖水平的感知.
主要成果:
- 高龄 (OR=1.05) 和胰岛素使用 (OR=0.29) 是不感知高血糖的独立决定因素.
- 低估计的淋巴膜过率 (eGFR) 是不感知低血糖的独立决定因素 (OR=0.94).
- 没有感知高血糖症被定义为时间超出范围 (TAR) ≥25%,DTSQ分数为0或+1.
- 没有感知低血糖症被定义为时间低于范围 (TBR) ≥4%,DTSQ分数为0或+1.
结论:
- 感知和实际葡萄糖水平之间的差异与非胰岛素使用,老年和功能障碍有关.
- 这些发现强调了在糖尿病护理中考虑个体因素的重要性.
- 基于这些见解,可以制定个性化糖尿病管理策略.
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